Willow Springs 2021 football on kuku 100.3
| Aug 27 | Clever at | Willow Springs | |
| Sep 3 | Willow Springs at | Marionville | |
| Sep 10 | Cabool at | Willow Springs | |
| Sep 17 | Mountain Grove at | Willow Springs | |
| Sep 24 | Willow Springs at | MV-BT/Liberty | |
| Oct 1 | Willow Springs at | Salem | |
| Oct 8 | Houston at | Willow Springs | |
| Oct 15 | Willow Springs at | Thayer | |
| Oct 22 | Ava at | Willow Springs |
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Thayer 2021 football
| Aug 27 | Thayer at | Hayti | |
| Sep 3 | Highland (Ark.) at | Thayer | |
| Sep 10 | MV-BT/Liberty at | Thayer | |
| Sep 17 | Thayer at | Salem | |
| Sep 24 | Houston at | Thayer | |
| Oct 1 | Thayer at | Cabool | |
| Oct 8 | Thayer at | Ava | |
| Oct 15 | Willow Springs at | Thayer | |
| Oct 22 | Thayer at | Mountain Grove |
Salem 2021 football
| Aug 27 | Salem at | St. James | |
| Sep 3 | St. Clair at | Salem | |
| Sep 10 | Salem at | Houston | |
| Sep 17 | Thayer at | Salem | |
| Sep 24 | Salem at | Ava | |
| Oct 1 | Willow Springs at | Salem | |
| Oct 8 | Mountain Grove at | Salem | |
| Oct 15 | Salem at | MV-BT/Liberty | |
| Oct 22 | Salem at | Cabool |
Liberty 2021 football
| Aug 27 | Liberty at | Strafford | |
| Sep 3 | Fair Grove at | MV-BT/Liberty | |
| Sep 10 | Liberty at | Thayer | |
| Sep 17 | Ava at | MV-BT/Liberty | |
| Sep 24 | Willow Springs at | MV-BT/Liberty | |
| Oct 1 | Liberty at | Mountain Grove | |
| Oct 8 | Liberty at | Cabool | |
| Oct 15 | Salem at | MV-BT/Liberty | |
| Oct 22 | Houston at | MV-BT/Liberty |
Mountain Grove 2021 football
| Aug 27 | MG at | Fair Grove | |
| Sep 3 | Caruthersville at | Mountain Grove | |
| Sep 10 | Ava at | Mountain Grove | |
| Sep 17 | MG at | Willow Springs | |
| Sep 24 | Cabool at | Mountain Grove | |
| Oct 1 | MV-BT/Liberty at | Mountain Grove | |
| Oct 8 | MG at | Salem | |
| Oct 15 | MG at | Houston | |
| Oct 22 | Thayer at | Mountain Grove |
Houston 2021 football
| Aug 27 | Sarcoxie at | Houston | |
| Sep 3 | St. James at | Houston | |
| Sep 10 | Salem at | Houston | |
| Sep 17 | Houston at | Cabool | |
| Sep 24 | Houston at | Thayer | |
| Oct 1 | Ava at | Houston | |
| Oct 8 | Houston at | Willow Springs | |
| Oct 15 | Mountain Grove at | Houston | |
| Oct 22 | Houston at | MV-BT/Liberty |
Cabool 2021 football
| Aug 27 | Cabool at | Miller | ||||
| Sep 3 | Cabool at | Ash Grove | ||||
| Sep 10 | Cabool at | Willow Springs | ||||
| Sep 17 | Houston at | Cabool | ||||
| Sep 24 | Cabool at | Mountain Grove | ||||
| Oct 1 | Thayer at | Cabool | ||||
| Oct 8 | MV-BT/Liberty at | Cabool | ||||
| Oct 15 | Cabool at | Ava | ||||
| Oct 22 | Salem at | Cabool | ||||
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| Ava 2021 football
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| Aug 27 | Buffalo at | Ava | ||||
| Sep 3 | Strafford at | Ava | ||||
| Sep 10 | Ava at | Mountain Grove | ||||
| Sep 17 | Ava at | MV-BT/Liberty | ||||
| Sep 24 | Salem at | Ava | ||||
| Oct 1 | Ava at | Houston | ||||
| Oct 8 | Thayer at | Ava | ||||
| Oct 15 | Cabool at | Ava | ||||
| Oct 22 | Ava at | Willow Springs | ||||
West Plains 2021 football
| Aug 27 | Glendale* at | West Plains | |
| Sep 3 | WP at | Hillcrest | |
| Sep 10 | Rolla at | West Plains | |
| Sep 17 | WP at | Camdenton | |
| Sep 24 | Kickapoo at | West Plains | |
| Oct 1 | WP at | Lebanon | |
| Oct 8 | Parkview at | West Plains | |
| Oct 15 | WP at | Waynesville | |
| Oct 22 | WP at | Bolivar |
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